UK and Ireland Distributor of Chimerigen - Advanced Immune Checkpoint Proteins, Interleukins and Other Cytokines
Chimerigen
The collaboration between Chimerigen and AdipoGen International allows us to bring the Chimerigen product range to to our customers in the UK and Ireland.
The Experts for High Quality Fusion Proteins
For many years Chimerigen Laboratories, LLC (Chimerigen) has developed & manufactured high quality and leading edge proteins for biomedical and immunology research. One of Chimerigen's specialties is the production of unique immunoglobulin based chimeric fusion proteins using advanced cellular and molecular biological techniques. These reagents are used successfully in basic and applied research. AdipoGen has now become a trusted and reliable marketing and sales partner for Chimerigen's product panel. Because of the high performance characteristics and quality the Chimerigen fusion proteins are widely recognized reagents and are cited in many scientific publications.
Non-lytic Ig-based Chimeric Fusion Cytokines with Long Circulating Half-life
The potential clinical application of cytokines to modulate immune responses is very high. Unfortunately, most cytokines have short circulating half-lives. Therefore, to facilitate the study of cytokine effects in vivo, a variety of non-lytic immunoglobulin-based chimeric cytokine fusion proteins have been created, in which a cytokine sequence had been genetically fused to the hinge, CH2 and CH3 regions of an immunoglobulin.
These non-lytic fusion proteins possess both the biological functions of the cytokine moiety and a prolonged circulating half-life determined by the Fc domain. They retain the potential to direct immune cytolytic mechanisms, antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against cellular targets bound by the amino terminal binding moiety. These fusion molecules also have the promise of being minimally to negligibly immunogenic since they are made entirely from elements derived from the species to be treated.
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Selected High Quality Fusion Proteins from Chimerigen
Fc Fusion Proteins:
- Product Code: CHI-HF-210A4 - Description: CD152 [CTLA-4] (human):Fc (human) (rec.)
- Product Code: CHI-MF-110A4 - Description: CD152 [CTLA-4] (mouse):Fc (mouse) (rec.)
- Product Code: CHI-HF-21002 - Description: IL-2 (human):Fc (human) (rec.)
- Product Code: CHI-HF-21006 - Description: IL-6 (human):Fc (human) (rec.)
- Product Code: CHI-HF-21015M - Description: IL-15 (mutant) (human):Fc (human) (rec.)
- Product Code: CHI-HF-21115MBI - Description: IL-15 (mutant) (human):Fc (mouse) (rec.) (Biotin)
- Product Code: CHI-HF-210T1 - Description: Tim-1 (human):Fc (human) (rec.)
- Product Code: CHI-HF-210T3 - Description: Tim-3 (human):Fc (human) (rec.)
- Product Code: CHI-HF-210T4 - Description: Tim-4 (human):Fc (human) (rec.)
- Product Code: CHI-HF-210TGFBM - Description: TGFβ1 (mutant) (human):Fc (human) (rec.)
Non-lytic Fc Fusion Proteins:
- Product Code: CHI-MF-120A4 - Description: CD152 [CTLA-4] (mouse):Fc (mouse) (rec.) (non-lytic)
- Product Code: CHI-HF-22002 - Description: IL-2 (human):Fc (human) (rec.) (non-lytic)
- Product Code: CHI-MF-12002 - Description: IL-2 (mouse):Fc (mouse) (rec.) (non-lytic)
- Product Code: CHI-HF-22004 - Description: IL-4 (human):Fc (human) (rec.) (non-lytic)
- Product Code: CHI-MF-12004 - Description: IL-4 (mouse):Fc (mouse) (rec.) (non-lytic)
- Product Code: CHI-HF-22006 - Description: IL-6 (human):Fc (human) (rec.) (non-lytic)
- Product Code: CHI-MF-12006 - Description: IL-6 (mouse):Fc (mouse) (rec.) (non-lytic)
- Product Code: CHI-HF-22010 - Description: IL-10 (human):Fc (human) (rec.) (non-lytic)
- Product Code: CHI-MF-12010 - Description: IL-10 (mouse):Fc (mouse) (rec.) (non-lytic)