Leinco Technologies Inc. - In vivo antibodies, isotype controls, biosimilars and more. Distributed in the UK & Ireland by Caltag Medsystems
Leinco Technologies Inc.
Leinco Technologies is a biotechnology company founded in 1992 as a specialty manufacturer of early discovery research products including antibodies, recombinant proteins, ELISA kits, second-step reagents, and other life sciences products.
Shortly thereafter, they also established themselves as a premier provider of custom Research & Development and manufacturing services focusing on monoclonal antibodies and recombinant proteins.
Their innovative products and services are used to augment the early discovery process in life science research, diagnostics, and groundbreaking development of protein therapeutics.
Read More About the Products Available:
- In Vivo Functional Grade Antibodies
- Isotype Control Antibodies
- Primary Antibodies
- Secondary Antibodies
- PhenoCycler-Fusion (CODEX)® Spatial Biology
- Biosimilars
- Antibodies by Research area: Infectious Diseases, Immune Checkpoints, Neuroscience
- Recombinant Proteins
- IVD Raw Materials
- Custom Services
Leinco's In Vivo Functional Grade Antibodies – In vivo GOLD™ and In vivo PLATINUM™
In vivo antibodies from Leinco serve the purpose of research applied in living animals or cells, for cell depletion, activation, neutralisation, blocking & many more.
Leinco Technologies has developed proprietary methods for manufacturing in vivo functional grade antibodies with the highest purity standards in the industry. The two quality standards of in vivo antibodies are: In vivo GOLDTM and In vivo PLATINUMTM.
In vivo GOLDTM antibodies contain no preservatives, stabilisers or carrier proteins and have a low endotoxin level of ≤ 1.0 EU/mg.
Leinco's in vivo PLATINUM™ antibodies have the most stringent quality specifications for purity, endotoxins, aggregates, and leachable protein A. In vivo PLATINUMTM antibodies have a low endotoxin level of ≤ 0.5 EU/mg. Each antibody is available in custom concentrations and package sizes. In vivo PLATINUM™ antibodies are also pathogen free and tested by the IDEXX Impact I PCR mouse pathogen profile.
Find out more about In vivo GOLDTM and In vivo PLATINUMTM antibodies
Leinco's Isotype Control Antibodies
Leinco Technologies manufactures ultra-pure isotype control antibodies with the highest purity specifications available for in vivo preclinical studies, diagnostic assay controls or research assay controls. They also offer high purity immunoglobulins, purified from normal animal serum for use in a variety of assay applications. Most of these isotype control antibodies are also conjugated to a wide range of fluorescent dyes or enzymes.
Leinco's Primary Antibodies for oncology, neuroscience, immunology, apoptosis and other
Leinco Technologies manufactures an extensive range of primary antibodies for scientists to assure the level of their research is world class and generates reliable data for publications.
Leinco's antibodies have the highest purity specifications available in the research products industry and each lot produced is validated for specificity and clone identity.
Leinco offers primary antibodies for research in oncology, neuroscience, immunology, apoptosis, signal transduction and many other research areas of interest.
Find out more about Monoclonal vs. Polyclonal Antibodies
Leinco Technologies has a growing range of recombinant chimeric antibodies, mAbMods™, which offer many advantages over those produced from traditional hybridoma technology.
Leinco's Secondary Antibodies
Leinco Technologies offers a wide range of second step reagents including secondary antibodies, streptavidin and UltraAvidin™, a deglycosylated form of avidin. Leinco applies its 35 plus years' experience in conjugation chemistry to manufacture a wide spectrum of fluorescent and enzyme conjugates for use in a variety of applications such as IHC, fluorescent microscopy, flow cytometry, western blotting, ELISA, and other applications.
Leinco's PhenoCycler-Fusion (CODEX)® Spatial Biology reagents and services
Leinco Technologies is your go-to source for PhenoCycler-Fusion (CODEX)® reagents and services. The PhenoCycler-Fusion (CODEX)® imaging technology for spatially resolved, highly multiplexed biomarker analysis is from Akoya Biosciences.
Leinco provides high quality barcoded antibodies ‘Ready to Stain', reporter molecules (fluorophore-conjugated oligonucleotides) & PhenoCycler-Fusion validated antibodies.
PhenoCycler-Fusion (CODEX)® ‘Ready to Stain' antibodies are validated according to tissue preparation, such as fresh frozen (FF) or fresh frozen paraffin-embedded (FFPE), and by tissue screened, such as liver, spleen, tonsil, brain, etc.
PhenoCycler-Fusion (CODEX)® Barcoded Antibodies
Ready-to-use high quality PhenoCycler-Fusion (CODEX)® barcoded antibodies and complementary fluorophore-conjugated oligonucleotides are available for spatial biology experiments. All DNA barcoded antibodies for PhenoCycler-Fusion (CODEX)® have undergone multiple levels of validation and verification to assure conjugated antibodies are free of unconjugated antibodies and DNA barcodes.
Fluorophore reporter molecules are conjugated to complementary oligonucleotides and matched with barcoded antibodies. The four distinct fluorescent reporter molecules include Alexa Fluor™ 488 (green channel), Alexa Fluor 647 (far-red channel), Alexa Fluor 750 (infrared channel), and Atto 550 (yellow channel).
PhenoCycler-Fusion (CODEX)® Validated Antibodies
Leinco Technologies offers purified PhenoCycler-Fusion (CODEX)® Ready antibodies that are "Ready to Conjugate" to oligonucleotides (barcodes). These antibodies are formulated in conjugation ready buffers to minimise the antibody preparation needed when performing a PhenoCycler-Fusion (CODEX)® barcode conjugation.
Find out more about PhenoCycler-Fusion (CODEX)® Technology and Workflow Steps
Leinco's Biosimilars
Leinco Technologies is a leader in the development and manufacturing of recombinant antibodies for early discovery research and diagnostics. They offer an extensive line of recombinant biosimilar antibodies at the in vivo functional purity levels you know and trust from Leinco Technologies. Recombinant biosimilar antibodies are designated for research use only and may not be used for therapeutics. Their biosimilars are made available to researchers to avoid purchasing therapeutic antibodies at pharmaceutical prices for important groundbreaking experiments.
Leinco's Antibodies by Research area: Infectious Diseases, Immune Checkpoints, Neuroscience
Infectious Diseases
Infectious diseases have been causing epidemics in our communities since ancient times. Since its rise in early 2020, COVID-19 has affected every person in one way or another and does not seem to be stopping anytime soon. COVID-19 is not alone in its category. There are a multitude of infectious diseases that are equally as capable (in particular, viral diseases) continuing to emerge.
Leinco Technologies understands that research is critical to understanding and managing these diseases. Their infectious disease antibodies and proteins catalogue includes monoclonal and polyclonal antibodies and a range of recombinant proteins to help advance your infectious disease research.
Immune Checkpoints
Leinco Technologies offers a wide range of well-known immune checkpoint antibodies for use in cancer research. Leinco is the premier manufacturer of in vivo functional grade antibodies with the highest purity specifications available. When conducting immune checkpoint preclinical research, it is important to use high purity in vivo grade antibodies to generate reliable data.
Leinco Technologies offers both GOLD™ and PLATINUM™ In vivo functional grade antibodies to important checkpoint markers for use in checkpoint research.
Neuroscience
The nervous system is responsible for a portion of nearly everything we do, from coordinating our bodily functions to our own consciousness. Studying the basics of how this system works can help develop treatments for debilitating neurological, psychiatric, and neurodegenerative disorders such as Alzheimer's disease, epilepsy, depression, schizophrenia, ALS, and neuro-oncology.
When studying neuroscience, researchers examine the role of nearly every type of cell and tissue in the body, as well as how this vast network interacts. To understand the complex and nuanced role of the many different cell types and tissues are involved, it is critical that researchers have dependable reagents that can generate reproducible and high quality science.
Leinco produces antibodies with the most stringent quality standards in the industry, providing unmatched reliability for your most important in vitro and in vivo neuroscience assays.
Leinco's Recombinant Proteins
Leinco has built a reputation on providing researchers with biologically active recombinant proteins, from a variety of host cells, that produce reliable research data. Leinco often selects mammalian expression systems using Chinese Hamster Ovary (CHO) or Human Embryonic Kidney (HEK) cells as the host to achieve the highest level of biological activity.
In addition, Leinco provides custom services to express and purify any protein you may require to conduct world-class research. They can also help scale up your expression system and purification by providing you with bulk, custom packaged proteins.
Leinco also offer monoclonal and polyclonal antibodies for most proteins. They are all produced in an animal-free, cGMP-compliant facility under their ISO quality system.
Leinco's Protein Specifications:
- >95% Purity for most proteins
- Longer storage and stability
- Bulk proteins re-assayed to assure high biological activity
- All proteins are Carrier Free/Low Endotoxin
Leinco's IVD Raw Materials
Matched Pairs
The development of in vitro diagnostics (IVD) kits based on immunoassays, such as lateral flow tests (LFT) and enzyme-linked immunosorbent assay (ELISA) relies on the availability of high-quality matched pairs of antibodies to capture and detect target analytes. It can be a challenge to find off-the-shelf and confirmed antibody pairs with the high sensitivity, specificity, purity, and stability needed to ensure an IVD kit meets performance requirements. Leinco has taken the guesswork out of finding antibodies for diagnostic raw materials, offering only the best-confirmed pairs.
Antigens & Conjugates
Antigens and hapten conjugates are critical components of IVD diagnostic tests and are necessary to show that a test is both sensitive and specific. They often serve as positive controls for lateral flow tests and ELISA to ensure that a test is working correctly and that the antibodies used detect the molecules of interest. Incorporated for standard curve generation, they provide a reference for determining the concentration of targets of interest.
To be used in IVD test, all components must have exceptional purity and lot-to-lot reproducibility, and in the case of many antigens, may need to retain their function. All products from Leinco are manufactured in world-class facilities including in dedicated class 10K cleanrooms. Their manufacturing processes adhere to current Good Manufacturing Practices (cGMP's) and the ISO 9001:2015 or ISO 13485:2016 quality standards.
Assay Buffers
Leinco manufactures a range of high-quality assay reagents including substrates, coating buffers, blocking buffers, wash buffers and stop solutions. 30 years in the life science industry has allowed Leinco to accumulate a great deal of assay development knowledge.
Secondary Antibodies & Controls
Leinco Technologies offers a wide range of second step reagents including secondary antibodies, streptavidin and UltraAvidin™, a deglycosylated form of avidin. Leinco then uses its 35+ years' experience in conjugation chemistry to manufacture a wide spectrum of fluorescent and enzyme conjugates for use in a variety of applications such as IHC, fluorescent microscopy, flow cytometry, western blotting, ELISA and more.
Custom Services
Leinco Technologies offers a variety of custom services, including:
- Custom IVD Antibodies and Protein Production
- Immunoassay Development
- Monoclonal Antibody Manufacturing
- Antibody Conjugation
- Antibody Barcoding
- Transient Antibody Expression
- Monoclonal Antibody Development
- Cell Banking, Optimisation and Adaptation
- Protein Purification
Caltag Medsystems is here with you every step of the way to support your custom project with Leinco Technologies. To find out more, please contact us.