TargetMol

Tigloylgomisin H

Product Code:
 
TAR-TN2272
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN2272-1mg1mg£109.00
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TAR-TN2272-5mg5mg£165.00
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TAR-TN2272-1mL1 mL * 10 mM (in DMSO)£199.00
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TAR-TN2272-10mg10mg£230.00
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TAR-TN2272-25mg25mg£343.00
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TAR-TN2272-50mg50mg£451.00
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TAR-TN2272-100mg100mg£596.00
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  • Further Information
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Further Information

Bioactivity:
Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway and can be used in liver cancer prevention studies.
CAS:
66069-55-4
Formula:
C28H36O8
Molecular Weight:
500.58
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
COc1cc2C[C@H](C)[C@@](C)(O)Cc3cc(OC)c(OC)c(OC)c3-c2c(OC(=O)C(C)=CC)c1OC
Target:
Nrf2

Documents

References

Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.