TargetMol

Robalzotan

Product Code:
 
TAR-T24721
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
Robalzotan is a selective 5-HT1A receptor antagonist.
CAS:
169758-66-1
Formula:
C18H23FN2O2
Molecular Weight:
318.392
Purity:
0.98
SMILES:
NC(=O)c1ccc(F)c2OC[C@@H](Cc12)N(C1CCC1)C1CCC1

Documents

References

1. Pittal? V, Siracusa MA, Salerno L, Romeo G, Modica MN, Madjid N, Ogren SO. Analysis of mechanisms for memory enhancement using novel and potent 5-HT1A receptor ligands. Eur Neuropsychopharmacol. 2015 Aug;25(8):1314-23. doi: 10.1016/j.euroneuro.2015.04.017. Epub 2015 Apr 29. PubMed PMID: 25963581. 2. Brenna E, Gatti FG, Malpezzi L, Monti D, Parmeggiani F, Sacchetti A. Synthesis of robalzotan, ebalzotan, and rotigotine precursors via the stereoselective multienzymatic cascade reduction of ?,?-unsaturated aldehydes. J Org Chem. 2013 May 17;78(10):4811-22. doi: 10.1021/jo4003097. Epub 2013 May 8. PubMed PMID: 23611252. 3. Eriksson TM, Delagrange P, Spedding M, Popoli M, Math? AA, ?gren SO, Svenningsson P. Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration. Mol Psychiatry. 2012 Feb;17(2):173-84. doi: 10.1038/mp.2010.131. Epub 2011 Jan 18. PubMed PMID: 21242991; PubMed Central PMCID: PMC3265836. 4. Kehr J, Hu XJ, Yoshitake T, Wang FH, Osborne P, Stenfors C, Ogren SO. The selective 5-HT(1A) receptor antagonist NAD-299 increases acetylcholine release but not extracellular glutamate levels in the frontal cortex and hippocampus of awake rat. Eur Neuropsychopharmacol. 2010 Jul;20(7):487-500. doi: 10.1016/j.euroneuro.2010.03.003. Epub 2010 Apr 21. PubMed PMID: 20413275.