TargetMol

AZD8329

Product Code:
 
TAR-T14383
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
AZD8329 is a potent inhibitor of 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1)(IC50 of 9 nM for human 11β-HSD1), and displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3.
CAS:
1048668-70-7
Formula:
C25H31N3O3
Molecular Weight:
421.541
Pathway:
Metabolism
Purity:
0.98
SMILES:
CC(C)(C)c1c(cnn1-c1ccc(cc1)C(O)=O)C(=O)NC1C2CC3CC(C2)CC1C3
Target:
Dehydrogenase

Documents

References

1. Scott JS, et al. Novel acidic 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J Med Chem. 2012 Nov 26;55(22):10136-47.