Biotinylated Human Mesothelin (C-6His-Avi)

Product Code:

ELK-EPT283

Product Group:

Other Proteins

Host Type:

Human

Regulatory Status:

RUO

Shipping:

The product is shipped at ambient temperature.

Storage:

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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Code	Size	Price

ELK-EPT283-100ug

100ug

£1,239.00

Quantity:

Prices exclude any Taxes / VAT

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Further Information

Accession:

AAH09272.1

Alternative Names:

Megakaryocyte potentiating factor; mesothelin; Pre-pro-megakaryocyte-potentiating factor; soluble MPF mesothelin related protein; CAK1; MPF; MSLN; SMR; CAK1; CAK1 antigen

Apparent Molecular Weight:

38-60 KDa, reducing conditions

Background:

Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Mesothelin plays an important role in cell survival, proliferation, migration, invasion, tumor progression, and resistance to chemotherapy. The overexpression of mesothelin can activate NF-κB and signal transducer and activator of transcription 3 (Stat3), inhibit apoptotic signaling and TNF-α-induced apoptosis, and accelerate the G1?S transition. Mesothelin is also found overexpressed in various cancers, including malignant mesothelioma, pancreatic or ovarian carcinoma, sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues, mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy.

Biological Activity:

Loaded Anti-Human Mesothelin mAb-Fc(Cat#NC078) on Protein A Biosensor, can bind Biotinylated Human Mesothelin-His-Avi(Cat#CY05) with an affinity constant of 10^-3 nM as determined in BLI assay.

Endotoxin:

Less than 0.1 ng/ug (1 EU/ug) as determined by LAL test.

Molecular Weight:

36.7 KDa

Purity:

Greater than 95% as determined by reducing SDS-PAGE.

Redissolve:

Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100ug/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.?