TargetMol

Desmethyl-QCA276

Product Code:
 
TAR-T18601
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T18601-100mg100mgEnquire
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TAR-T18601-500mg500mgEnquire
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Further Information

Bioactivity:
Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].
CAS:
2126819-55-2
Molecular Weight:
387.46
Purity:
0.98
SMILES:
C(#CC=1SC2=C(C1CC=3C=CC=CC3)COCC4=NN=C(N42)C)C=5C=NNC5

Documents

References

Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.