TargetMol

Z-LEHD-fmk

Product Code:
 
TAR-T21835
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T21835-1mg1mg£230.00
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TAR-T21835-5mg5mg£568.00
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TAR-T21835-10mg10mg£775.00
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TAR-T21835-25mg25mg£1,099.00
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Quantity:
TAR-T21835-50mg50mg£1,476.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis.Z-LEHD-FMK exhibits antitumor and neuroprotective activity, increases the yield of in vitro-produced preimplantation embryos of Bubalus bubalis and alters the cellular stress response.
CAS Number:
210345-04-3
Formula:
C32H43FN6O10
Molecular Weight:
690.72
Purity:
98%
SMILES:
[C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC(C)C)=O)CCC(OC)=O)=O)C(N[C@@H](CC(OC)=O)C(CF)=O)=O
Target:
Apoptosis; Caspase

Documents

References

1.Ozoren N, et, al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2000 Nov 15; 60(22): 6259-65. 2.Mocanu MM, et, al. Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. Br J Pharmacol. 2000 May; 130(2): 197-200. 3.Colak A, et, al. Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury. J Neurosurg Spine. 2005 Mar; 2(3): 327-34.