TargetMol

Amyloid-Forming peptide GNNQQNY

Product Code:
 
TAR-T83122
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental in amyloid fibril formation. Its atomic oligomeric structure has been detailed, serving as an excellent model for investigating early-stage aggregation. The peptide can form three stable β-sheet structures: in-register parallel, off-register parallel, and anti-parallel. Notably, the in-register parallel dimer aligns closely with amyloid β-sheet architecture, relying on fewer interpeptide hydrogen bonds and emphasizing hydrophobic interactions, which enhances conformational entropy relative to the anti-parallel arrangement.
CAS Number:
339091-39-3
Formula:
C33H48N12O14
Molecular Weight:
836.81
Purity:
98%
SMILES:
[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)CC(N)=O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CC(N)=O)=O)CC(N)=O)=O)CCC(N)=O)=O)CCC(N)=O

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