TargetMol

PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His)

Product Code:
 
TAR-TMPK-01290
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-01290-100ug100ugEnquire
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TAR-TMPK-01290-1mg1mgEnquire
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TAR-TMPK-01290-500ug500ugEnquire
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Further Information

Bioactivity:
PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 23.73 kDa and the accession number is A0A2K5U5Z4.
Molecular Weight:
23.73 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Yearley JH, et al. PD-L2 Expression in Human Tumors: Relevance to Anti-PD-1 Therapy in Cancer. Clin Cancer Res. 2017;23(12):3158-3167. doi:10.1158/1078-0432.CCR-16-1761