TargetMol

CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)

Product Code:
 
TAR-TMPK-01299
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-01299-100ug100ugEnquire
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TAR-TMPK-01299-1mg1mgEnquire
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TAR-TMPK-01299-500ug500ugEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated.
Molecular Weight:
72.76 kDa (predicted). Due to glycosylation, the protein migrates to 120-200 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Li Q, et al. FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis. Int J Biol Sci. 2018;14(7):726-735. Published 2018 May 12. doi:10.7150/ijbs.24505