TargetMol

GPVI Protein, Cynomolgus, Recombinant (His)

Product Code:
 
TAR-TMPK-01302
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-01302-100ug100ugEnquire
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TAR-TMPK-01302-1mg1mgEnquire
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TAR-TMPK-01302-500ug500ugEnquire
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Further Information

Bioactivity:
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands. GPVI Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.42 kDa and the accession number is XP_005590417.2.
Molecular Weight:
26.42 kDa (predicted). Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Rayes J, et al. Functional significance of the platelet immune receptors GPVI and CLEC-2. J Clin Invest. 2019 Jan 2;129(1):12-23. doi: 10.1172/JCI122955. Epub 2019 Jan 2. PMID: 30601137; PMCID: PMC6307936.