TargetMol

IL-12B Protein, Cynomolgus, Recombinant (His)

Product Code:
 
TAR-TMPK-01378
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-01378-100ug100ugEnquire
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TAR-TMPK-01378-1mg1mgEnquire
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TAR-TMPK-01378-500ug500ugEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
Interleukin (IL)-12B, which encodes the p40 subunit common to IL-12 and IL-23, as one of the genes for which expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLS) is induced by DcR3.Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor-like ligand 1A (TL1A), to prevent their effects. Recent studies have suggested that DcR3 directly affects cells as a ligand.
Molecular Weight:
35.86 kDa (predicted). Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Fukuda K, et al. Interleukin?12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts. Mol Med Rep. 2016 Apr;13(4):3647-52. doi: 10.3892/mmr.2016.4985. Epub 2016 Mar 7. PMID: 26956410.