TargetMol

TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)

Product Code:
 
TAR-TMPK-01382
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-01382-100ug100ugEnquire
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TAR-TMPK-01382-1mg1mgEnquire
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TAR-TMPK-01382-500ug500ugEnquire
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Further Information

Bioactivity:
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Molecular Weight:
26.1 kDa (predicted). Due to glycosylation, the protein migrates to 49-60 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Vanamee, et al. TNFR2: A Novel Target for Cancer Immunotherapy[J]. Trends in Molecular Medicine, 2017:S1471491417301697.