TargetMol

SETD7 Protein, Human, Recombinant (His)

Product Code:
 
TAR-TMPY-01229
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-TMPY-01229-100ug100ugEnquire
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  • Further Information
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Further Information

Bioactivity:
Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysine methyltransferase (PKMT), SETD7 also has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF1, and possibly TAF7 by recognizing and binding in substrate proteins. The mono-methyltransferase activity of SETD7 is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction. SETD7 is also a novel coactivator of NF-kappaB and plays a role in inflammation and diabetes.
Molecular Weight:
41.5 kDa (predicted)
Purity:
98%

References

1.Wang, H. et al., 2002, Mol Cell?8?(6): 1207-17. 2.Jacobs, SA. et al., 2002, Nat. Struct. Biol.?9?(11): 833-8. 3.Xiao B, et al., 2003, Nature. 421 (6923): 652-6. 4.Martens, JH. et al., 2003, Mol. Cell. Biol. 23: 1808-1816.Couture, JF. et al., 2006, Nat Struct Mol Biol??13?(2): 140-6.