TargetMol

J chain Protein, Human, Recombinant (His)

Product Code:
 
TAR-TMPY-01918
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-TMPY-01918-100ug100ugEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Immunoglobulin J chain, also known as IGJ and IGCJ, is a secreted polypeptide which is the first immunoglobulin-related polypeptide expressed during the embryogenesis and differentiation of B cells in the fetal liver. The joining Immunoglobulin J chain is a small polypeptide, expressed by mucosal and glandular plasma cells, which regulates polymer formation of immunoglobulin (Ig)A and IgM. Immunoglobulin J chain / IGJ serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA, it induces larger polymers. Immunoglobulin J chain / IGJ also helps to bind these immunoglobulins to the secretory component. J-chain incorporation into polymeric IgA (pIgA, mainly dimers) and pentameric IgM endows these antibodies with several salient features. Immunoglobulin J chain / IGJ is involved in creating the binding site for pIgR / SC in the Ig polymers, not only by determining the polymeric quaternary structure but also by interacting directly with the receptor protein. Both the immunoglobulin J chain / IGJ and the pIgR/SC are key proteins in secretory immunity.
Molecular Weight:
17 kDa (predicted)
Purity:
98%

References

1.Zikan, J. et al.,?1985,?Proc Natl Acad Sci USA. 82?(17): 5905-9. 2.Koshland, M.E.?et al., 1985, Annu Rev Immunol. 3: 425-53.Iwase,T. et al., 1993, Cell Struct Funct. 18?(5): 297-302. 3.Johansen, F.E. et al., 2000, Scand J Immunol. 52?(3): 240-8. 4.Lim, J.H.?et al., 2006,?J Immunol. 177?(8): 5420-9.