XCT Antibody / SLC7A11

Immunohistochemistry (FFPE): 1-2ug/ml

Optimal dilution of the recombinant xCT antibody should be determined by the researcher.

xCT, also known as SLC7A11 (solute carrier family 7, (cationic amino acid transporter, y+ system) member 11) or CCBR1, is a 501 amino acid multi-pass membrane protein that belongs to the polyamine-organocation superfamily of amino acid transporters. Existing as a disulfide-linked heterodimer with CD98, xCT functions as a member of a heteromeric Na+-independent anionic amino acid transport system that specifically facilitates the exchange of anionic amino acids for anionic forms of cystine and glutamate, thereby mediating the formation of glutathione within the cell. Due to its involvement in amino acid transport, xCT is associated with the pathogenesis of gliomainduced neurodegeneration and brain edema, as well as pancreatic cancer. The gene encoding xCT maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

A recombinant fragment of human SLC7A11 protein was used as the immunogen for the recombinant xCT antibody.

This recombinant xCT antibody is available for research use only.

Cytoplasm, membrane

Protein A/G affinity

Q9UPY5