Further Information
Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1
For WB starting dilution is: 1:1000
Tryptases comprise a family of trypsin-like serine
proteases, the peptidase family S1. Tryptases are enzymatically
active only as heparin-stabilized tetramers, and they are resistant
to all known endogenous proteinase inhibitors. Several tryptase
genes are clustered on chromosome 16p13.3. These genes are
characterized by several distinct features. They have a highly
conserved 3' UTR and contain tandem repeat sequences at the 5'
flank and 3' UTR which are thought to play a role in regulation of
the mRNA stability. These genes have an intron immediately upstream
of the initiator Met codon, which separates the site of
transcription initiation from protein coding sequence. This feature
is characteristic of tryptases but is unusual in other genes. The
alleles of this gene exhibit an unusual amount of sequence
variation, such that the alleles were once thought to represent two
separate genes, alpha and beta 1. Beta tryptases appear to be the
main isoenzymes expressed in mast cells; whereas in basophils,
alpha tryptases predominate. Tryptases have been implicated as
mediators in the pathogenesis of asthma and other allergic and
inflammatory disorders.
- Lee, J.W., et al. Dig. Dis. Sci. 55(10):2922-2928(2010)
- Trivedi, N.N., et al. J. Allergy Clin. Immunol. 124(5):1099-1105(2009)
- Radhakrishnan, Y., et al. Biol. Reprod. 81(4):647-656(2009)
- Schiemann, F., et al. J. Immunol. 183(4):2223-2231(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Human
This TPSAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-275 amino acids from the C-terminal region of human TPSAB1.
7177
Tryptase alpha/beta-1
TPSAB1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
31 kDa
Q15661
18202508
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle,Immunology,Obesity,Signal Transduction
Q15661
Optimal dilutions for each application to be determined by the researcher.